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Sustained weight loss was maintained over extended treatment durations of up to 104 weeks in STEP 5 [40], while efficacy was also consistent across ethnically diverse populations, as demonstrated in STEP 6 [41] and STEP 7 [43]

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The article says eligibility often turns on underlying metabolic risk rather than weight alone, and names elevated fasting glucose, prediabetes, insulin resistance, elevated triglycerides and a family history of type 2 diabetes as factors that can make a lower-BMI patient a candidate

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