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During the epoxidation of squalene, catalyzed by squalene epoxidase (encoded by the SQLE gene
It stimulates the pituitary rather than replacing GH directly, making it relevant to research involving pituitary responsiveness, endogenous hormone release, IGF-1 regulation, and endocrine feedback
SURMOUNT-1 reported up to 22.5% mean body-weight reduction at the highest studied dose over 72 weeks
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