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kidney function assessments in these studies primarily served safety monitoring purposes

Wang X, You J, Tang J, Li X, Wang R, Li Y, et al

478,479,480 Figotinib is a selective JAK1 inhibitor that regulates the activity of the immune system by inhibiting specific signaling pathways, thereby reducing inflammation and improving intestinal symptoms

The MHRA-approved SmPC specifically warns that dehydration from these gastrointestinal effects may precipitate acute kidney injury, which could present with reduced urine output