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However, be prepared for a potential return of nausea when you increase to 0.5 mg in week five
A separate Phase 3 trial called ATTAIN-MAINTAIN, also disclosed in the Q4 deck, showed that patients switching from injectable semaglutide or tirzepatide to oral orforglipron maintained their weight loss over 52 weeks of extension
If you are transitioning from semaglutide to retatrutide, allow a washout period of at least 5-7 half-lives of the outgoing compound before beginning the retatrutide escalation
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