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The discovery set the stage for a decade of GLP-1 research and development, culminating in newer formulations with greater efficacy and longer dosing intervals

This work, published by Anisimov et al

Specifically, stronger connections between bilateral ventromedial prefrontal cortices and dorsal prefrontal cortices are associated with higher depressive scores, indicating that altered neural circuitry may underlie mood disturbances in this population [104]