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They found three miRNAs, miR-470, -669b, and -681, were upregulated in these mice and these three miRNAs directly bound to IGF-1R 3UTR, downregulated IGF-1R at both mRNA and protein levels, and led to reduced phosphorylation of both AKT and FOXO3a
Phentermine/topiramate (Qsymia): Topiramate is a once-daily medication used to treat seizures and prevent migraines
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