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During the COVID-19 pandemic, individuals with thyroid diseases (mostly autoimmune) showed lower adherence to the MeD, higher prevalence of overweight, and reduced physical activity compared with controls, further supporting the benefits of healthy lifestyle choices [176]

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Notably, history of cardiovascular disease was present in 86.9% of participants from SURPASS-4, whereas the prevalence of such conditions in the other trials was 5.418.3% (Supplementary Table 3)

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