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If you dont supplement and your B12 is high, thats the finding your doctor needs to investigate
Without intrinsic factor, the ileum can no longer absorb the B 12
Consult your healthcare team for any persistent side effects or concerns
Recent structural studies of therapeutically relevant agonists like tirzepatide have revealed that its weaker affinity for GLP-1R compared to GIPR stems from a bulkier N-terminal Tyr1 causing steric conflicts with W306, resulting in biased pharmacology with reduced receptor desensitization
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