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These improvements are typically more pronounced when the injections are part of a comprehensive program including healthy nutrition and physical activity

Unintentional weight loss, more likely driven by comorbid disease, excessively impacts metabolically active tissue over fat mass [45]

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The peptide carries 2-aminoisobutyric acid substitutions at positions 2 and 20 to resist dipeptidyl peptidase-4 degradation, a C-terminal amide, an N6-substituted lysine C18-diacid fatty acyl side chain for albumin binding and half-life extension, and a 2-methyl leucine substitution for selectivity tuning