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These studies suggest that GLP-1 and its receptor play a role in the pathophysiology of congenital hyperinsulinism and that targeting the GLP-1 receptor may be an effective treatment approach for this condition ( ATP hyperinsulinism and decreases glucose infusion rate requirements in infants with K ATP hyperinsulinism ( Role of GLP-1 in Hyperinsulinemic Hypoglycemia Secondary to Gastric Surgery Plasma glucose homeostasis, particularly in the post-prandial state is altered after gastric surgery, including gastrectomy, fundoplication, and bariatric procedures ( via increased GLP-1 release potentiating insulin secretion

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