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Clinical trials have demonstrated weight loss ranging from approximately 10% with GLP-1 agents at weight management doses (e.g., semaglutide 2.4 mg in the STEP trials) to over 20% with tirzepatide at higher doses (SURMOUNT trials)

Overall, it promotes glowy, healthy-looking skin

Nausea, abdominal discomfort, or gastroesophageal refluxall documented with tirzepatidecan interfere with sleep onset and maintenance

And in my field, when you chronically overstimulate a signaling pathway the nervous system depends on for normal function, things tend to go wrong in ways that may be quiet at first but get much louder later