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As expected, hepsin / mice displayed heightened oxidative stress after APAP exposure compared to wild-type mice, indicated by a significant decrease in GSH and an increase in nitrotyrosine levels, leading to more severe liver damage and mortality
Maiese K, Chong ZZ, Shang YC, Hou J (2008) Therapeutic promise and principles: metabotropic glutamate receptors
Key Takeaway: Glutathione is the body's primary internal defense against oxidative stress, but its "power" is focused on general cellular protection and liver support
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