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In research models, GLP-1 receptor activation is associated with glucose-dependent insulin secretion, suppression of glucagon release, slowed gastric emptying, and reduced food intake through central appetite-regulating circuits

But because it slows the rate of stomach emptying and alters hunger cues, the first weeks can come with nausea, constipation, diarrhea, reflux, and abdominal discomfort

It sounds counterintuitive, but if your calories drop too low (below 1,000 to 1,200), your body enters metabolic adaptation (starvation mode) and holds onto fat

Nausea is one of the most common adverse effects of semaglutide, affecting up to 20-30% of patients, and this can be exacerbated by dental procedures, particularly those involving sedation, antibiotics, or pain medications