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The SURMOUNT-1 trial (N=2,539), published in the New England Journal of Medicine in 2022 (DOI: 10.1056/NEJMoa2206038), evaluated tirzepatide at 5mg, 10mg, and 15mg weekly doses versus placebo in adults with obesity or overweight
Oral and injectable routes serve different purposes and use different dose ranges
Solution turns cloudy after initial clarity A solution that was clear after reconstitution but turns cloudy during storage typically indicates protein aggregation due to temperature excursion (the vial got too warm or too cold) or bacterial contamination
However, their psychomotor impairment will actually be increasing for many hours
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