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The incretin effect can account for at least 40% of the insulin produced postprandially in healthy individuals, and a loss of response to both endogenous GLP-1 and GIP, along with the subsequent deterioration of the incretin effect, is an early characteristic of T2DM (Nauck et al., 1993

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It has previously been suggested that the GT II assay is able to reliably detect mixed infections if the minor genotype/subtype represents at least 2030% of the circulating variants (similarly to Sanger sequencing) 13,35

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