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Our results showed that 10 M BAY 11-7082 effectively inhibited the nuclear translocation of NF-B p65 and the mRNA expression of Bax and P53 , but increased the mRNA expression of Bcl2 and Bcl-xL in the peroxynitrite + BAY 11-7082 group compared with the peroxynitrite-only group, as well as in the peroxynitrite + gpx1 / + BAY 11-7082 group compared with the peroxynitrite + gpx1 / group (Figures 9AC)
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TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation
Meanwhile, structural damage was observed in mitochondria, accompanied by increases in ROS and malondialdehyde (MDA), as well as decreases in GSH and GPX4
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