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Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression

Glutathione works by donating electrons to neutralize reactive oxygen species (ROS) generated during alcohol metabolism, preventing the lipid peroxidation and mitochondrial damage that manifest as fatigue and brain fog

Caspase-6 knockout in 5xFAD mice on the other hand has reduced A pathology and improved performance in anxiety assessment compared to 5xFAD alone (Gao et al., 2018)

Therefore, in addition to GSSG accumulation, a decrease in Grx expression/activity may also lead to increased protein S -glutathionylation