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The sudden or gradual onset of diffuse mucosal pigmentation in adulthood, even in darkerskinned patients, should alert the clinician to contemplate a pathologic genesis

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Adults using a GLP-1 had an increase in GFR from 50.48 mL/min/1.73 m 2 at baseline to 53.44 mL/min/1.73 m 2 at 6 months, whereas the control group had a decrease from 43.4 mL/min/1.73 m 2 at baseline to 40.84 mL/min/1.73 m 2 at 6 months ( P = .03)

It was the first signal that the Phase 2 results were going to hold up at scale, and it was also where the dysesthesia signal first appeared prominently