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We have also presented biochemical mapping data showing that a dsDNA binding interface resides within the disordered C-terminal region of PDS5B, allowing us to construct a compound point mutant that is defective in DNA binding
The most common were nausea (28.6%, 38.4% and 42.4% vs 14.8%), diarrhoea (25.2%, 34.1% and 32.0% vs 13.5%), constipation (23.8%, 25.9% and 26.1% vs 10.9%), vomiting (10.6%, 22.8% and 25.3% vs 4.8%), and upper respiratory tract infection (14.2%, 12.2% and 13.1% vs 11.6%)
Mice were single-housed on a 12-h light/dark cycle with free access to food and water and fed a high-fat diet ad libitum (Research Diets, D12492
Regularly monitor VYVANSE-treated patients for the emergence or worsening of tics or Tourette's syndrome, and discontinue treatment if clinically appropriate
