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Most patients begin with low-dose injections to minimize nausea and allow metabolic adaptation, then gradually increase based on tolerance and clinical response
Higher weight loss (1% reduction in weight from baseline was associated with a 3.1% [95% CI, 2.9%-3.2%] lower hazard of discontinuation for patients with type 2 diabetes and a 3.3% [95% CI, 3.2%-3.5%] lower hazard of discontinuation for patients without type 2 diabetes) and higher income (type 2 diabetes only
Recruitment of -arrestin-2 was also slightly reduced with lixisenatide compared to exendin-4 (Figure 2B
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