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We report here the hormonal, metabolic and gonadal responses to the glucagon-like peptide-1 (GLP1)-based multi-agonists, GLP1/Estrogen (GLP1/E), GLP1/gastric inhibitory peptide (GLP1/GIP) and GLP1/GIP/Glucagon, in two mouse PCOS models, with variable penetrance of metabolic and reproductive traits, and their comparison with metformin

"To date, only 1 other study has examined gestational weight gain after GLP-1RA use," and "only a handful" have looked at links between the drugs and other adverse pregnancy outcomes, epidemiologists Carolyn Cesta , Jennifer Hutcheon and Kari Johansson wrote in a commentary of the new research

While most of the time these do have additional benefits, usually the amounts are so small that they dont make much of a difference so an additional supplement is likely necessary

Key takeaways: Patients with diabetes prescribed GLP-1 receptor agonists had lower one-year mortality regardless of OSA status