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Protein-tyrosine nitration is a post-translational chemical modification process for the highly selective non-enzymatic introduction of a nitro group (-NO 2 ) into the side chain by peroxynitrite (ONOO - ), a short-lived biomolecule generated by the rapid reaction of NO with superoxide radicals in vivo 40,41

Dose escalation speed, meal size, food choices, and hydration may also affect symptoms

It is unknown whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans

Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice