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Though supplementation of withanolide A during exposure to hypobaric hypoxia significantly decreased the number of caspase positive cells as well as hoescht positive cells in the CA3 region of hippocampus compared to hypoxic group treated with vehicle only, combined administration of buthionine sulfoximine along with Withanolide A during hypoxic exposure significantly elevated the number of apoptotic cells in CA3 region of hippocampus compared to hypoxic group treated with Withanolide A only and vehicle treated group (Fig