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Moderate to Severe Deficiency: For moderate to severe deficiencies, the dosage may increase to 1,000 mcg several times a week initially, followed by a maintenance dose
For example, in the SUSTAIN 5 clinical trial, patients with HbA1c levels of 8.0% or lower had their basal insulin doses reduced by 20% when starting semaglutide therapy to minimize the risk of low blood sugar
Some of the variable costs include the location of the clinic and the practitioners expertise
Some protocols use a frontloaded approach with higher frequency in early weeks, then maintain at 3x/week
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