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Patients should contact their healthcare provider if they experience large or expanding bruises that continue to grow over several days, as this may indicate ongoing bleeding or a hematoma requiring assessment
The American Diabetes Association's Standards of Care emphasizes that patience during this titration period is essential for both efficacy and tolerability
However, theres no clear consensus in the literature, and studies that find benefits do so following at least two weeks of daily supplementation (typically around 2 grams/day)
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