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Additionally, GSH shifts the melanogenesis pathway away from eumelanin (the darker brown/black pigment) toward pheomelanin (the lighter red/orange pigment) by interacting with dopaquinone intermediates in the Raper-Mason pathway
The lactate leads to acidification of the environment and stabilization of activated HIF-1 in the interior region which then reinforces glycolysis in the interior region by upregulating GLUT1, LDHA, and hexokinase 2 (HK2), key proteins involved in the glycolytic pathway
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At least 70 enzymes utilize coenzyme A for the metabolism of fat, protein, carbohydrates and proper functioning of citric acid cycle (13)
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