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Active malignancy or recent cancer history requires extremely careful evaluation
180,181 Motor symptoms include progressive weakness and atrophy of proximal lower-limb muscles, leading to difficulty rising from a seated position or climbing stairs, accompanied by muscle fasciculations and hyporeflexia
This is the case for serotonin, gamma-aminobutyric acid (GABA), nitric oxide (NO), and endogenous opioids
It also modulates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), which helps clear damaged proteins and prevent excessive breakdown of the extracellular matrix
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