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42 Interestingly, islet beta-cells express reduced levels of antioxidant enzymes to deal with ROS compared to other cell types, 51,52 indicating that ROS must be useful to these cells
At 2 months of age, male and female tamoxifen-inducible cellspecific Glp-1r cell+/+ (WT) and Glp-1r cell/ (KO) littermates were placed on a HFD consisting of ground chow (5012 LabDiets) supplemented with 3.4% butter fat, 8.5% tallow, 13.1% soybean oil, 3.5% mineral mix, and 1% vitamin mix (Dyets) for 6 weeks
Small amounts of avocado or olive oil are usually well-tolerated, whereas large amounts of fried food often cause issues
Currently, there is no direct evidence that GLP-1RA use contributes to progression of pancreatic cysts to PDAC, but this remains an important knowledge gap for future investigations considering the high prevalence of pancreatic cysts in the general population (~ 10% by age 50 and ~25% by age 70) 56
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