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This secondary analysis of the STEP-HFpEF (Semaglutide Treatment Effect in People with Obesity and HFpEF) program reveals that semaglutide provides benefits for men and women that do not track directly with weight loss, suggesting the drug may also have weight-loss independent effects on the cardiovascular system
Renal carnitine loss may also affect the morphology and function of red blood cells and reduce the oxygen carrying and releasing capacity of red blood cells, thereby reducing tissue oxygen supply (including the kidney), and tissue hypoxia activates hypoxia-inducible factor 1 (HIF-1), which in turn reduces OCTN2 expression through the HIF-1-PPAR signaling pathway
For example, Zepbound and Mounjaro contain both GLP-1 and tirzepatide, which is a glucose-dependent insulinotropic polypeptide (GIP) receptor
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
