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Autophagy deficiency in neurons results in buildup of ubiquitinated proteins, dystrophy of neural terminals, impairments in synaptic transmission, and eventually, neurodegeneration observed in both neurodegenerative and neurodevelopmental disorders [245, 249, 250]
Additional considerations include patients with uncontrolled diabetes or rapid correction of hyperglycemia, those with depression or suicidal ideation, and individuals who are pregnant or planning to become pregnant, as the drug may interfere with contraception and requires monitoring
Role of iron metabolism in heart failure: From iron deficiency to iron overload
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