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3-MT 3-methoxytyramine Catechol-O-methyltransferase (COMT) inhibitors reduce the breakdown of levodopa to its inactive metabolite, 3-O-methyldopa, increasing bioavailability and duration of action, which is useful for addressing end-of-dose wearing-off phenomena: Entacapone is the most commonly used agent and can be added at a standard dose of 200mg to each dose of levodopa, up to a total of 2000mg per day
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Generalized skin symptoms that may warrant attention include widespread itching (pruritus) without visible rash, development of hives (urticaria), or unexplained rashes
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