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Injection of HGF plasmid cDNA to prevent manifestation of Parkinson disease: a preclinical study using a primate model

A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

This promotes the generation, strengthening, and maintenance of synapses in brain regions such as the cerebral cortex, hippocampus, and striatum, thereby improving learning, motor, and cognitive functions (la De Rosa et al., 2020

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