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In addition, gene therapy can enhance cellular antioxidant capacity by upregulating the expression of antioxidant enzymes, thus reducing ROS accumulation
Simultaneously, the AMPK pathway, which may play a significant role in maintaining energy homeostasis, might be indirectly affected by IGF-1 analogs such as IGF-1 LR3
This adaptive response suggests the peptide stimulates compensatory intestinal hypertrophy and improved absorptive capacity
Preclinical evidence in rodent and mouse models was encouraging
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