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Semaglutide with B12 has the same contraindications and potential side effects as semaglutide, including the risk of thyroid C-cell cancer (such as multiple endocrine neoplasia syndrome type 2), pancreatitis, hypoglycemia, and serious allergic reactions
Also, intranasal delivery generally produces fewer systemic side effects due to reduced peripheral exposure
3.7 Other PCT substances identification All results are summarized in Table 2
additive with GLP-1 Semaglutide Established CV outcomes Tirzepatide Highest single-agent obesity efficacy Retatrutide Triple-agonist mechanism Numbers reflect published Phase 3 endpoints where available
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