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(iii) upregulate fatty acid translocase, which is the enzyme that moves circulating NEFAs into adipocytes, so less NEFAs are available for infiltration into the liver
Though subsequent events after protein binding were cause for controversy initially (detailed in the section on ferroptosis), progress in resolving this issue was made when it was shown that an oxidant stress was not observed during metabolism of APAP [23, 24] but only after the drug metabolism phase was completed, and that the oxidant stress was located within mitochondria [25, 26]
Carnitine: transport and physiological functions in the brain
Within the combination options, incretin-based therapies will play a relevant role, given that most patients with MASH have T2DM or obesity, conditions in which these are already commonly used
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