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Coronado, M
Thanks to the distinct characteristics of nanoparticles which include improved targeting, ability to control the drug release and low toxicity in the systemic circulation, the nanotechnology allows for precise regulation of oxidative stress in tumour cells [40,41,42]
Lysophosphatidylcholine acyltransferase-3 (LPCAT3) and acyl-CoA synthetase long chain family member 4 (ACSL4) are the crucial enzymes regulating PUFAs biosynthesis and remodeling by catalyzing AA to phospholipid (PL) hydroperoxide (PL-OOH, such as AA-OOH), which are considered specific biomarkers and drivers of ferroptosis (Xu et al., 2020
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