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Fischbach, F
Tirzepatide significantly reduced body weight and improved glucose tolerance in HFD-fed mice without altering -cell mass, proliferation, or apoptosis
This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption
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