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Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements
Virtus Peptides does not independently re-test it
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Brewster LM, Garcia VP, MaV L, Stockelman KA, Goulding A, DeSouza NM, Greiner JJ, Hijmans JG, DeSouza CA (2020) Endothelin-1-induced endothelial microvesicles impair endothelial cell function
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