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Furthermore, exendin-4 has been shown to attenuate lipotoxicity-induced glomerular endothelial cell dysfunction in diabetic ApoE-deficient mice by increasing the ABC transporter A1-mediated cholesterol efflux (Yin et al., 2016)
After binding to GLP-1 receptors, a cascade of reactions occurs: Insulin is released to lower blood sugar Slower gastric emptying Satiety increased GLP-1 medications do the same thing
Such neuronal changes, or lesions, are characterized by tangles of nerve fibers and the increased presence of -amyloid and hyperphosphorylated tau in the brain, which ultimately leads to a decline in nervous system function
doi: 10.1056/NEJMoa1411892 21 RubinoDMGreenwayFLKhalidUO'NeilPMRosenstockJSrrigRet al
