One should focus on fruits, vegetables, whole grains, lean proteins and healthy fats, limit intake of processed foods, sugary treats and excessive alcohol and to include antioxidant-rich foods such as berries to reduce inflammation [19]
The STAT3 factors induce the expression of SOCS proteins which consequently inhibit the function of JAK/STAT3 signaling, i.e., SOCS proteins exert a negative feedback on the JAK/STAT3 signaling induced by both insulin/IGF-1 and certain cytokine pathways
While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)
however, there are other factors that may trigger or worsen psoriasis