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Based on this evidence, multidisciplinary guidelines have listed GLP 1RAs as first - line or preferred treatment options for patients with type 2 diabetes and/or obesity with high cardiovascular risk [51, 52]

A potential additional advantage of GIP is the protection against hypoglycemia since GIP infusion is accompanied by a decreased need for further glucose administration to maintain a satisfactory glycemic level during an insulin-induced hypoglycemic clamp [15]

F., Quesnel, D

Given that altered expression and activity of DPP-4 are associated with increasing body mass index and hyperglycaemia, DPP-4 has been proposed to play a role in linking obesity and the pathogenesis of T2DM by functioning as a local mediator of inflammation and insulin resistance in adipose and hepatic tissue