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Enzymatic cleavage of albumin results in less efficient FcRn-mediated rescue from lysosomal degradation and, consequently, a dramatically shorter plasma half-life of 3.5 days in humans 60
Based on these observations, we designed peptides in which the individual hydrophobic residues were substituted with alanine
Moreover, elevated mtROS levels can exacerbate the maintenance of mtDNA
Secondary endpoints included between-group laboratory profile comparisons and Cohort 2 ACE1/ACE2 plasma levels
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