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Li-Weber M, Giaisi M, et al

The established tight inverse relationship between stroke volume and heart rate in POTS in which tachycardia functions as a compensatory response to inadequate stroke volume rather than a primary dysrhythmia indicates that pharmacological perturbations that reduce venous return or peripheral vascular tone are likely to be hemodynamically consequential in this population (Sheldon et al., 2019)

Practical Considerations For GHK-Cu topical alone: Applied once daily after cleansing

Medicinal products containing unknown active substances at unknown concentration pose a significant risk to patients, as an existing illness may remain untreated and possible adverse reactions cannot be determined