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Our clinicians need reminding that Pernicious anaemia (PA) is the very tip of a huge iceberg
Glucagon is also involved in acutely regulating glucose homeostasis and administration of pharmacological doses of glucagon in animal models for diabetes or obesity has demonstrated regulatory effects on lipid metabolism, energy expenditure, and food intake ( The GLP-1/glucagon agonist cotadutide (MEDI0382) is the compound of this dual-receptor agonist class that is the most advanced in clinical development
Consistent with the role of KG in carnitine synthesis, we also observed an increase in DNA damage foci upon TMLHE knockdown, which was rescued by L-carnitine and acetylcarnitine, but not KG, propionyl-carnitine, or butyryl-carnitine ( Fig
Cancer 1977
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