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European Journal of Medicinal Chemistry

Given the differences in the MedDRAs categorization rules, some potential PTs that were not included may exist, e.g., depression suicidal (belonging to HLGT level, depressed mood disorders and disturbances) and intentional overdose (belonging to HLGT level, overdoses, and underdoses NEC)

Fluconazole inhibits CYP3A4, increasing domperidone exposure, while both medications can prolong the QT interval, significantly increasing the risk of Torsades de Pointes and other serious ventricular arrhythmias