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The study contributed to a developing preclinical literature suggesting AOD-9604 may have applications in joint and cartilage research distinct from its original metabolic indication
Sun thinks that a way to overcome these hurdles is to continue trying to understand more of the biological processes modulating the deterioration
Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits
Oral B12 supplements rely on a complex absorption pathway in the gut involving a protein called intrinsic factor
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