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In contrast, eight of the 10 states with the lowest share of patients on GLP-1s are located in the Western U.S., where obesity prevalence tends to be lower

Source numerical data are available in the source data

Light exposure also contributes to degradation, particularly for peptides containing tryptophan, tyrosine, methionine, or cysteine residues

Clinical trials have documented gastrointestinal side effects (nausea, constipation, abdominal pain) in a significant proportion of patients, and these symptoms may occasionally manifest as referred pain to the back region