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These are well tolerated by most people with little to no pain, apart from the sensation of a sharp scratch

Consequently, we show that several thiol-containing compounds, including dithiothreitol, N-acetyl-L-cysteine, and glutathione, perform a nucleophilic attack on the amoxicillin molecule that is followed by an internal rearrangement leading to amoxicillin diketopiperazine, a known amoxicillin metabolite with residual activity

The results were expressed in micromoles per deciliter and reported as changes from the baseline values

Importantly, HER-2/neu overexpression is a clinically relevant target in human breast cancers, making this model highly translational for cancer risk mitigation in susceptible populations