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P21 has similarly shown the ability to reverse dendritic and synaptic density loss caused by traumatic brain injury, restoring the physical architecture of neural connections that had been damaged
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Polysomnography (a sleep study) was conducted on healthy individuals and depressed patients, revealing that SSRIs can lead to decreased sleep efficiency and total sleep time, longer time to fall asleep, and disrupted sleep continuity with more awakenings and wake time during sleep
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