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dose reductions may be needed Rosuvastatin: exposure increased by about 41%, but this is not considered clinically relevant No clinically relevant interaction was seen with digoxin, oral contraceptives (ethinylestradiol/levonorgestrel), metformin, furosemide or omeprazole

Patients should seek medical advice if headaches are accompanied by: Neurological symptoms : Vision changes, weakness, numbness, difficulty speaking, confusion, or loss of consciousness Severe nausea and vomiting : Particularly if unable to maintain adequate hydration or take medications for more than 24 hours Signs of dehydration : Markedly decreased urination, dark urine, dizziness, rapid heartbeat, or dry mucous membranes Fever or neck stiffness : Which may suggest infection requiring evaluation Changes in headache pattern : New characteristics in patients with pre-existing headache disorders New onset after age 50 : Headaches beginning later in life require evaluation Severe, persistent abdominal pain with or without vomiting : May indicate pancreatitis, a rare but serious side effect of GLP-1 medications requiring immediate medical attention Healthcare providers may recommend several approaches when evaluating persistent headaches

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If a patient is uninsured or stuck in coverage gap, RTBC may tell that too, prompting early financial counseling or copay assistance programs